Timeframe: 2014 – 2015 Goal: Support series of high priority FLC investigations Principal Investigator: Sandy Simon, PhD Study background: In previous work (including the initiatives funded in 2010 and 2011), the study team identified an increase of a patient’s antibodies, in particular the antibody known as IgG (immunoglobin G), in fibrolamellar, sarcomas, and a number …
Timeframe: 2013 – 2014 Goal: Support costs related to establishment of new FLC biospecimen storage facility Principal Investigator: Sandy Simon, PhD Study background: Access to tumor tissue is critical to help cancer researchers understand what drives a disease and how the cancer responds to treatments. Because fibrolamellar is so rare, there has long been a …
Timeframe: 2013 – 2016 Goal: Conduct genomic-based analysis of FLC patients Principal Investigator: Ron DeMatteo, MD Study background and overview: At the time of this effort, little was known about the exact mutations driving fibrolamellar carcinoma. Published research on the genomic alterations in FLC was scarce and limited to small studies, with the largest comprised …
Timeframe: 2013 – 2014 Goal: Identify genetic mutations in FLC Principal Investigator: Sandy Simon, PhD Study background: The goal of this project was to identify genetic mutations present in FLC. Identification of mutations common in FLC tumors is critical to enhancing the understanding of the underlying biology of this tumor and allow for development of …