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Goal: Determine if T cells can be generated that react to FLC’s characteristic fusion protein Principal Investigator: Ephraim Fuchs, MD Grant length: One year Study overview: In FLC, the characteristic DNAJB1-PRKACA fusion creates a novel protein with a unique amino acid sequence occurring at the junction of these two proteins. This unique amino acid sequence …
Goal: Identify optimal culture conditions for FLC organoidsPrincipal Investigator: Jian Liu, PhD Grant length: One year Study overview: Scientific investigators often use cultures, dishes containing tumor cells, to test candidate treatments for a disease. The type of cultures that most accurately reflect the properties of cells as if they were inside the body are “organoids”, …
Goal: Validating the RNA signature, expression and function in FLCPrincipal Investigator: Praveen Sethupathy, PhD Grant length: Two years Study overview: In past work at UNC, a survey of numerous drugs under consideration for FLC use proved non-effective or minimally effective in limiting the growth of the first FLC tumor model. This indicated that completely new …