Retinoic acid-induced loss of DNAJB1-PRKACA fusion protein expression

Timeframe: 2019-2022 Goal: Investigate the potential of retinoic acid therapy Principal Investigator: Andrew Yen, PhD, Professor, Department of Biomedical Sciences Co-Principal Investigator: Praveen Sethupathy, PhD, Associate Professor, Department of Biomedical Sciences FLC is driven by the DNAJ-PKAc fusion protein. A potential therapeutic strategy would be to induce loss of this key driver protein. One approach …

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