Characterizing enzyme inhibition of the DnaJPKAc chimeric protein derived from fibrolamellar hepatocellular carcinomas
Goal: Characterize inhibition of the DnaJ-PKAc chimeric protein in fibrolamellar carcinoma Principal Investigator: Hibba tul Rehman, MD Grant length: One year Study overview: The DNAJB1-PRKACA fusion gene produces the DNAJ-PKAc fusion kinase protein, which is present in nearly all FLC tumors and promotes liver tumor formation in mice. Kinases, including fusion kinases, have been successful …