Our new AI assistant can help patients, caregivers, and researchers find important information faster. Click the logo in the lower right corner to try it.
Goal: Support costs related to establishment of new FLC biospecimen storage facility Principal Investigator: Sandy Simon, PhD Grant length: One year Study background: Access to tumor tissue is critical to help cancer researchers understand what drives a disease and how the cancer responds to treatments. Because fibrolamellar is so rare, there has long been a …
Goal: Model development Principal Investigator: Nabeel Bardeesy, PhD Grant length: Two years Study overview: While multiple FLC models have recently been developed, additional model development remains a priority for the FLC community. This effort aimed to develop multiple different FLC models as resources for the FLC research fibrolamellar cancer research community, collaborating with the Fibrolamellar …
Goal: Model development Principal Investigator: Mark Yarchoan, MD Grant length: One year Study overview: Efforts to identify novel therapies for FLC have been confounded by a lack of preclinical models that accurately reflect the genetics and biology of the disease. This study aimed to establish and validate the first orthotopic, syngeneic, preclinical mouse model of …
Goal: Model development Principal Investigator: Benedetta Artegiani, PhD Grant length: Two years Study Overview: Research into FLC is complicated because of the limited experimental tools that can be used to study this rare cancer. While tests in laboratory animals such as mice are useful tools, they do not reflect the human disease due to inherent …
Goal: Develop useful disease models to support subsequent research efforts Principal Investigator: Yuzhou Wang, PhD Grant length: One year Study overview: Availability of model system to replicate the disease is an essential tool in development of therapeutics. These model systems can be used by researchers for mechanistic investigations, rapid drug screening, and many other purposes. Model …
Goal: Identify biomarkers for FLC Principal Investigator: Michael Torbenson, MD (Currently at Mayo Clinic) Grant length: One year Study overview: Early identification of tumors is essential for aggressive treatment. The majority of fibrolamellar carcinoma (FLC) patients have metastatic disease at the time of diagnosis. Therefore, identification of biomarkers for FLC is essential. Using a broad …
Goal: Develop a pre-clinical mouse model for fibrolamellar carcinoma Principal Investigator: Julien Sage, PhD Grant length: One year Study overview: There are few effective therapies for FLC patients and development of improved therapeutics are hampered by the rarity of the disease and the challenge of including pediatric patients in many clinical trials. One solution to …
Goal: Use zebrafish as a model system for fibrolamellar carcinoma to study the immune system Principal Investigator: Sofia de Oliveira, PhD Grant length: Multiple years; part of CRI fellowship Study overview: Few FLC animal models currently exist limiting our ability to study FLC in the context of a complete organism. While cell-based models are extremely …
Goal: Generate a mouse model of FLC Principal Investigator: Sean Ronnekleiv-Kelly, MD Grant length: One year Study overview: The purpose of this study was to generate a robust pre-clinical murine model of FLC that can provide a basis for understanding factors contributing to FLC formation, and for therapeutic development. The study proposed to develop a …