DNAJB1-PKAc-β-catenin-ALCD-dependent activation of cancer genes plays an essential role in fibrolamellar hepatocellular carcinoma
Timeframe: 2020 – 2021 Goal: Document mechanisms driving FLC and test if treatment with inhibitors of b-catenin may be a potential therapeutic approach for FLC Principal Investigator: Nikolai Timchenko, PhD, Head of Liver Tumor Biology, Liver Tumor Program; Professor, UC Department of Surgery In the course of studies of pediatric liver cancer, we have identified …