How fibrolamellar carcinoma differs from hepatocellular carcinoma in children – Creation of a multi-institutional database including central pathologic review

Timeframe: 2023 – 2025 Goal: Understand the true incidence, accuracy of diagnosis, and optimal treatments for FLC Principal Investigator: Roshni Dasgupta, MD of the Cincinnati Children’s Hospital Medical Center Co-investigators: Study overview: In previous work, the Pediatric Surgical Oncology Research Collaborative (PSORC) collected and analyzed detailed records of 262 patients under age 20 diagnosed with …

Read more

DNAJB1-PKAc-β-catenin-ALCD-dependent activation of cancer genes plays an essential role in fibrolamellar hepatocellular carcinoma

Timeframe: 2020 – 2021 Goals: Document mechanisms driving FLC and test if treatment with inhibitors of β-catenin may be a potential therapeutic approach for FLC Principal Investigator:  Nikolai Timchenko, PhD Study overview: In the course of studies of pediatric liver cancer, the team at CCHMC has identified chromosomal regions (Aggressive Liver Cancer Domains, ALCDs) in …

Read more