Kinase fusion function investigation
Timeframe: 2016 – 2018 Goal: Investigate DNAJB1-PRKACA fusion kinase function in new fibrolamellar carcinoma models Principal Investigator: Dr. Yi Guo, Ph.D, Associate Consultant – Asst Professor, Dept of Biochemistry and Molecular Biology The DNAJB1-PRKACA fusion kinase is found in nearly 100% of FLC cases. While this novel fusion has been shown to promote tumors in …