Fibrolamellar Cancer Foundation

Molecular analysis of FLC tumors

Timeframe: 2013 – 2016 Goal: Conduct genomic-based analysis of FLC patients Principal Investigator: Ron DeMatteo, MD Study background and overview: At the time of this effort, little was known about the exact mutations driving fibrolamellar carcinoma. Published research on the genomic alterations in FLC was scarce and limited to small studies, with the largest comprised …

Everolimus clinical trial

Timeframe: 2010 – 2014 Goal: Assess potential of everolimus (RAD001) as a treatment option for FLC Principal Investigator: Ghassan Abou-Alfa, MD Study background and overview: At the time of this trial, the molecular drive of fibrolamellar, the DNAJB1-PRKACA fusion gene, had not been identified. However, several factors suggested that estrogen and estrogen-dependent pathways may play …