Discovery of the chimera genetic mutation

Timeframe: 2014 – 2015 Goal: Identify genetic mutations in FLC Principal Investigator: Sandy Simon, Ph.D., Professor, Rockefeller University The goal of this project was to identify genetic mutations present in FLC. The team used whole genome sequencing together with RNA sequencing to identify mutations in FLC tumors compared to their normal liver counterparts. Identification of …

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Developing therapeutics for fibrolamellar hepatocellular carcinoma

Timeframe: 2016 – 2017 Goal: Develop new therapeutics for FLC Principal Investigator: Sandy Simon, Ph.D., ProfessorInvestigator Collaboration: Barbara A. Lyons, Ph.D., Professor, New Mexico State University The goal of this work was to develop therapeutics for FLC. The team identified three independent strategies based on their laboratory’s work showing that a single common DNA alteration …

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