Timeframe: 2012 – 2013 Goal: Support series of projects exploring the role of antibody involvement in FLC tumors Principal Investigator: Sandy Simon, PhD Study overview: This effort continued the encouraging early work begun on mice to see if researchers could take advantage of the immune system to identify potential ways to detect and eventually treat …
Timeframe: 2010 – 2011 Goal: Build understanding of the immunology and cell biology of FLC using mouse models of cancer Principal Investigator: Sandy Simon, PhD Study background: This early study was designed to determine if researchers could take advantage of the immune system to identify potential ways to detect and eventually treat fibrolamellar. The immune …
Timeframe: 2014 – 2015 Goal: Support series of high priority FLC investigations Principal Investigator: Sandy Simon, PhD Study background: In previous work (including the initiatives funded in 2010 and 2011), the study team identified an increase of a patient’s antibodies, in particular the antibody known as IgG (immunoglobin G), in fibrolamellar, sarcomas, and a number …
Timeframe: 2013 – 2014 Goal: Support costs related to establishment of new FLC biospecimen storage facility Principal Investigator: Sandy Simon, PhD Study background: Access to tumor tissue is critical to help cancer researchers understand what drives a disease and how the cancer responds to treatments. Because fibrolamellar is so rare, there has long been a …
Timeframe: 2013 – 2014 Goal: Identify genetic mutations in FLC Principal Investigator: Sandy Simon, PhD Study background: The goal of this project was to identify genetic mutations present in FLC. Identification of mutations common in FLC tumors is critical to enhancing the understanding of the underlying biology of this tumor and allow for development of …
Timeframe: 2016 – 2017 Goal: Develop new therapeutics for FLC Principal Investigator: Sandy Simon, PhD Investigator Collaboration: Barbara Lyons, PhD (New Mexico State University) Study overview: The goal of this work was to identify potential therapeutic strategies to target FLC. The team identified three independent approaches to analyze based on their laboratory’s work showing that …