Discovery of the chimera genetic mutation

Timeframe: 2012 – 2014 Goal: Identify genetic mutations in FLC Principal Investigator: Sandy Simon, PhD Study background: The goal of this project was to identify genetic mutations present in FLC. The team used whole genome sequencing together with RNA sequencing to identify mutations in FLC tumors compared to their normal liver counterparts. Identification of mutations …

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Developing therapeutics for fibrolamellar hepatocellular carcinoma

Timeframe: 2016 – 2017 Goal: Develop new therapeutics for FLC Principal Investigator: Sandy Simon, PhD Investigator Collaboration: Barbara Lyons, PhD (New Mexico State University) Study overview: The goal of this work was to develop therapeutics for FLC. The team identified three independent strategies based on their laboratory’s work showing that a single common DNA alteration …

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