Targeting DNAJB1-PRKACA driven signaling dependencies in FLC
Timeframe: 2019 – 2022 Goal: Investigate the potential of AURKA inhibitors for FLC treatment Principal Investigator: John Gordan, MD, PhD, Assistant Professor, Department of Medicine, UCSF Co-Investigator: Nabeel Bardeesy, Associate Professor, Massachusetts General Hospital, Harvard University Even though the DNAJB1-PRKACA gene fusion (encoding a chimeric protein with a domain of heat shock protein 40, HSP40, …