Timeframe: 2019 – 2020 Goal: Identify optimal culture conditions for FLC organoidsPrincipal Investigator: Jian Liu, PhD Study overview: Scientific investigators often use cultures, dishes containing tumor cells, to test candidate treatments for a disease. The type of cultures that most accurately reflect the properties of cells as if they were inside the body are “organoids”, …
Timeframe: 2015 – 2017 Goal: Validating the RNA signature, expression and function in FLCPrincipal Investigator: Praveen Sethupathy, PhD Study overview: In past work at UNC, a survey of numerous drugs under consideration for FLC use proved non-effective or minimally effective in limiting the growth of the first FLC tumor model. This indicated that completely new …
Timeframe: 2010 – 2011 Goal: Understand the developmental biology of fibrolamellar carcinomaPrincipal Investigator: Lola Reid, PhD Study overview: Based on extensive work that Dr. Lola Reid’s Laboratory had already performed on normal liver cells and other forms of liver cancer, the goal of the effort was to attempt to define the development biology stage and …