University of Vermont Archives - Fibrolamellar Cancer Foundation

Liquid Biopsy for Active Surveillance of Fibrolamellar Hepatocellular Carcinoma

Timeframe: 2021 – 2022 Goal: Develop a blood-based screening method to detect relapse in FLC patients Principal Investigator: Gary S. Stein, PhD, Department of Biochemistry, University of Vermont Cancer Center This study is focused on developing a blood-based screening method to detect relapse in FLC patients that have been diagnosed and treated by surgery. This …

Characterizing enzyme inhibition of the DnaJPKAc chimeric protein derived from fibrolamellar hepatocellular carcinomas

Timeframe: 2017 – 2019 Goal: Characterize inhibition of the DnaJ-PKAc chimeric protein in fibrolamellar carcinoma Principal Investigator: Hibba tul Rehman, M.D., University of Vermont The DNAJB1-PRKACA fusion gene produces the DnaJ-PKAc fusion kinase protein, which is present in nearly all FLC tumors and promotes liver tumor formation in mice. Kinases, including fusion kinases, have been …