Fibrolamellar Cancer Foundation

Liquid Biopsy for Active Surveillance of Fibrolamellar Hepatocellular Carcinoma

Timeframe: 2021 – 2023 Goal: Develop a blood-based screening method to detect relapse in FLC patients Principal Investigator: Gary S. Stein, PhD Study overview: This study is focused on developing a blood-based screening method to detect relapse in FLC patients that have been diagnosed and treated by surgery. This screening protocol is intended to be …

Characterizing enzyme inhibition of the DnaJPKAc chimeric protein derived from fibrolamellar hepatocellular carcinomas

Timeframe: 2017 – 2019 Goal: Characterize inhibition of the DnaJ-PKAc chimeric protein in fibrolamellar carcinoma Principal Investigator: Hibba tul Rehman, MD Study overview: The DNAJB1-PRKACA fusion gene produces the DNAJ-PKAc fusion kinase protein, which is present in nearly all FLC tumors and promotes liver tumor formation in mice. Kinases, including fusion kinases, have been successful …