Timeframe: 2011
Goal: Profile microRNA in metastatic Fibrolamellar Carcinoma
Principal Investigator: Yuzhou Wang, PhD, University of British Columbia
MicroRNAs are small RNA species that regulate the expression of other genes and are important in many biological processes, including tumor development, growth, and metastasis. MicroRNAs have become increasingly useful as diagnostic markers, prognostic indicators, and therapeutic targets. This study examined the microRNA profile of FLC tumors which metastasize and matched tumors that do not metastasize. By identifying microRNAs that predict or lead to tumor metastasis, the study results may help to create new diagnostic and therapeutic tools and strategies.