This study sequenced the DNA from FLC tumors and compared the results to the DNA from non-cancerous tissue from the same patients to identify the specific mutations that had occurred in the cancer. In the 10 samples examined, the only consistent mutation was the DNAJB1-PRKACA fusion gene. Since the only consistent mutation found was the DNAJB1-PRKACA deletion, this mutation may be sufficient to cause the cancer. A few other mutations were found in more than one patient, including MUC4, GOLGA6L2, DSPP, FOXO6 and HLA-DRB1. However, in comparison to other cancers, fibrolamellar seems to have a relatively low tumor mutation burden.
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