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Immunotherapy-related efforts

Therapeutic modulation of tumor-infiltrating T cell function in fibrolamellar carcinoma

Goals: Identifying factors in the tumor environment that impair immune responses to FLC and defining potentially effective immunotherapy strategies Principal Investigators: Venu Pillarisetty, MD (University of Washington); and Kevin Barry, PhD (Fred Hutchinson Cancer Center) Grant length: Two years Study overview: Immunotherapy – harnessing patients’ immune systems to attack tumor cells – has become established …

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Cancer Research Institute (CRI) fellowship program – renewal

Goal: Develop and fund a series of three-year FLC research fellowships Grant length: Four years Overview: This grant extended FCF’s successful partnership with the prestigious Cancer Research Institute (CRI) to identify and staff three-year research fellowships for young researchers focusing on immunotherapy-related research for fibrolamellar. CRI has been promoting immunotherapy research for 65 years, long …

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Spatially resolving the tumor microenvironment of fibrolamellar carcinoma

Goal: Advance understanding of FLC’s unique tumor microenvironment Principal Investigator: Praveen Sethupathy, PhD Grant length: Two years Study overview: Through this grant, Praveen Sethupathy, PhD, of Cornell University plans to outline the “spatial transcriptomics” of FLC. Dr. Sethupathy’s lab has been a leader in functional genomic studies, especially for liver and gastro-intestinal cancers. His group …

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Defining the potential of DNAJB1-PRKACA fusion-specific T cells across human populations

Goal: Defining the most promising immunological targets that can be translated into effective cell-based immunotherapies Principal Investigators: Paul G. Thomas, PhD Grant length: Two years Study overview: New immunotherapeutic approaches have produced spectacular outcomes for a small subset of tumors, including certain melanomas, lung cancers, and leukemias, but these dramatic cures have not been broadly …

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Multicenter consortium to define the single-cell activity landscape of fibrolamellar carcinoma

Goals: Advance immunotherapy for FLC by defining promising immunological targets that can be translated into effective cell-based immunotherapies Principal Investigators: Praveen Sethupathy, PhD (Cornell University); Mark Yarchoan, MD (Johns Hopkins University); Paul G. Thomas, PhD (St. Jude Children’s Research Hospital) Grant length: Two years Study overview: Like tumors of other cancer types, the microenvironment of …

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Generation of T cells with specificity to FLC’s chimeric fusion

Goal: Determine if T cells can be generated that react to FLC’s characteristic fusion protein Principal Investigator: Ephraim Fuchs, MD Grant length: One year Study overview: In FLC, the characteristic DNAJB1-PRKACA fusion creates a novel protein with a unique amino acid sequence occurring at the junction of these two proteins.  This unique amino acid sequence …

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Cancer Research Institute (CRI) fellowship program

Goal: Develop and fund a series of three-year FLC research fellowships Grant length: Four years Overview: With this grant, FCF partnered with the prestigious Cancer Research Institute (CRI) to specifically focus on the role immunotherapy could have in creating curative therapies for fibrolamellar. CRI has been promoting immunotherapy research for 65 years, long before the …

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Pre-clinical studies of the interactions of the immune system with FL-HCC

Goal: Study the interactions between the immune system and FLC in a mouse model Principal Investigator: Kevin Barry, PhD Grant length: Multiple years; part of CRI fellowship Study overview: Cancer immunotherapies harness the power of the immune system to kill tumors. Checkpoint blockade immunotherapies are an exciting class of cancer immunotherapies that remove the brakes …

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