New: FCF Assistant

We’re testing a new AI assistant to help patients, caregivers, and researchers find information faster. Click the FCF Assistant button in the lower right corner to try it.

Immunotherapy-related efforts

Investigating immune checkpoint biomarkers in tissue and peripheral blood of patients with fibrolamellar hepatocellular carcinoma

Goal: Define the dominant immune checkpoint pathway in FLC Principal investigator: Amy K. Kim, MD Grant length: Multiple years; part of CRI fellowship Study overview: Tumor cells produce immune checkpoint molecules that suppress host immune response and allow evasion from immune responses. The discovery of drugs that block these immune checkpoints have revolutionized current cancer …

Read more

T cell immunotherapy in fibrolamellar cancer

Goal: Characterize T-cells in the FLC tumor microenvironment Principal Investigator: Kevin M. Sullivan, MD Grant length: Multiple years; part of CRI fellowship Study Overview: Immunotherapy is a form of cancer treatment that harnesses the patient’s own immune system to fight the disease. The immune system can precisely target cancer cells, while also minimizing damage to …

Read more

Modulating stromal-immune cell interactions to activate anti-tumor immunity to fibrolamellar carcinoma

Goal: Assess whether suppressing checkpoints or signaling by a specific chemokine (CXCL12) can enhance immune response in FLC Principal Investigator: Venu Pillarisetty, MD Grant length: One year Study overview: Immunotherapy, harnessing the patient’s immune system to precisely target cancer cells, has emerged as a promising approach to treat many cancers. It has been discovered that …

Read more