Fibrolamellar Cancer Foundation

Development of pre-clinical murine models for fibrolamellar hepatocellular carcinoma

Timeframe: 2023 – 2024 Goal: Immunocompetent mouse model development Principal Investigator: Julien Sage, PhD Study overview: Dr. Julien Sage has a very longstanding interest in FLC and is recognized as a world leader in the type of genetic modeling in mice proposed in this study. This study proposes to extend Dr. Sage’s team’s previous work …

Developing pre-clinical models for fibrolamellar FL-HCC: therapeutic target identification and testing

Timeframe: 2016 – 2019 Goal: Develop a pre-clinical mouse model for fibrolamellar carcinoma Principal Investigator: Dr. Julien Sage, PhD Study overview: There are few effective therapies for FLC patients and development of improved therapeutics are hampered by the rarity of the disease and the challenge of including pediatric patients in many clinical trials. One solution …