A new study, recently published in eLife by Dr. John Gordan of UCSF, elaborates some of the downstream effects of protein kinase A (PKA) in certain cancers, including fibrolamellar. Genetic alterations that activate PKA are found in many cancer types (such as the DNAJB1-PRKACA fusion in FLC), but how that signalling leads to cancer formation …
Amara Strande, a FLC patient, and her family have joined legislators in Minnesota to advocate for changes to protect communities from toxic chemicals. “2022 is the year my cancer became unstoppable,” 20-year-old Amara Strande said in her presentation to the committee. “They can’t do surgery this time. There are no more treatments to try,” Strande …
FCF is pleased to announce that we have awarded Dr. Venu Pillarisetty of the University of Washington a two-year grant entitled “Therapeutic modulation of tumor-infiltrating T cell function in fibrolamellar carcinoma (FLC)”. Immunotherapy – harnessing patients’ immune systems to attack tumor cells – has become established as an exceptionally promising approach for cancer treatment. Prior …
FCF has recently awarded John Gordan, MD, PhD of University of California San Francisco (UCSF) a one-year grant to study “Selective translational inhibition as a treatment strategy for fibrolamellar liver cancer.”This proof-of-concept proposal will focus on testing for activity of an investigational drug zotatifin (eFT226) against human FLC tumors grown in mice. Previously, Gordan’s work …
Unfortunately, Amazon has announced that their AmazonSmile charitable donation program is being discontinued as of February 20, 2023. Until that date, 0.5% of customer purchases made via AmazonSmile will continue to be directed towards a user’s choice of charity. We appreciate the support that this Amazon program has provided FCF over the last several years, …
FCF is pleased to announce a new one-year grant award to Mark Yarchoan of Johns Hopkins University in Baltimore, MD to support the development of a protocol for a potential clinical trial. In 2020, the Johns Hopkins team began a phase I clinical trial of an experimental vaccine containing a peptide (small segment of a …
FCF is pleased to announce that Dr. Nabeel Bardeesy of the Massachusetts General Hospital in Boston, MA has been awarded a new two-year grant entitled “Elucidation of nuclear-mitochondrial signaling by DNAJ-PKAc to define targeted vulnerabilities in FLC”. In fibrolamellar carcinoma (FLC) the development and growth of tumor cells is driven by the presence of the …
Each year on GivingTuesday, millions of people come together to celebrate generosity, share kindness and donate to causes they care about. A celebration of all types of generosity, GivingTuesday inspires people around the world to give gifts of money, time, skills, advocacy, and more. Everyone has something to give and every act of generosity counts. …
Kielan Wilson-Premo, a member of FCF’s Patient & Caregiver Advisory Board, recently shared his perspectives on mental health issues for patients facing a rare disease diagnosis and treatment. On October 17, Kielan served as a panelist for a discussion on “Mental Health and Rare Cancers” at the National Organization for Rare Disorders’ (NORD) annual Rare …